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Many pathogens require direct binding to, or penetration of, mucosal cells to cause pathology.
A neural-targeted drug should not cause pathology such as changes in the expression of particular genes that could cause an increase in intracellular proteins.
Physiologically, the intestine has developed several strategies to resist colonization by non-native bacteria and control the expansion of pathobionts that have the potential to cause pathology.
However, the mediators responsible for this protective role can inappropriately target self tissues and cause pathology in many inflammatory diseases, in ischaemia reperfusion injuries and also as a result of therapeutic intervention, such as in cardiopulmonary bypass.
Despite the enhanced efficacy of memory cells and the recall immune response, there are numerous experimental and empirical examples in which protection provided by vaccines are short-lived, particularly against pathogens that replicate and cause pathology at their site of entry.
In human patients, the loss of EF-G1 does not cause pathology in all tissues.
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There is also strong evidence that repetitive loading affect both discs and vertebrae, and can cause pathologies such as disc degeneration and disc hernias depending on load attributes (Parkinson & Callaghan 2009; Tsai et al. 1998; Yu et al. 2003).
Notably, RTK activation is tightly regulated in healthy adult tissues as aberrant signalling in susceptible cells can cause pathologies, such as cancer.
This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations, technical and animal care considerations, and data analysis methods.
These genes are nonessential for growth in tissue culture cells but are important for growth in postmitotic cells, interfering with intrinsic antiviral and innate immune responses or causing pathology, functions dispensable for replication in cancer cells.
De Grey defines it as metabolism, which continually causes damage and damage eventually causes pathology.
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CEO of Professional Science Editing for Scientists @ prosciediting.com