Exact(3)
There is also strong evidence that repetitive loading affect both discs and vertebrae, and can cause pathologies such as disc degeneration and disc hernias depending on load attributes (Parkinson & Callaghan 2009; Tsai et al. 1998; Yu et al. 2003).
Notably, RTK activation is tightly regulated in healthy adult tissues as aberrant signalling in susceptible cells can cause pathologies, such as cancer.
While increased random damage of existing molecules might not significantly contribute to aging, is it possible that TORC1-driven hyperfunction leads directly to the increased synthesis of rogue proteins that cause pathologies and compromise longevity?
Similar(57)
Many pathogens require direct binding to, or penetration of, mucosal cells to cause pathology.
A neural-targeted drug should not cause pathology such as changes in the expression of particular genes that could cause an increase in intracellular proteins.
Physiologically, the intestine has developed several strategies to resist colonization by non-native bacteria and control the expansion of pathobionts that have the potential to cause pathology.
However, the mediators responsible for this protective role can inappropriately target self tissues and cause pathology in many inflammatory diseases, in ischaemia reperfusion injuries and also as a result of therapeutic intervention, such as in cardiopulmonary bypass.
In human patients, the loss of EF-G1 does not cause pathology in all tissues.
Uncontrolled IL-1β, even at very low concentrations can cause pathology [7].
There is an ongoing debate in the literature on whether FHM2 mutations cause pathology by a loss- or a gain-of function mechanism [51].
However, they may also cause pathology when these productions are excessive or uncontrolled [ 45].
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