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Unlike α-synuclein, overexpressed β-synuclein does not cause pathological changes in the nervous system of transgenic mice and even ameliorates the pathology caused by overexpressed α-synuclein.
We postulate that this accumulation may cause pathological changes in the cells resembling some of those characteristic of age-related macular degeneration (AMD).
In all of the above examples, the mental disorder in question can cause pathological alternations in value that may impair decision-making capacity.
After nitrate administration, there was hepatocellular degeneration with increased intercellular space of the liver cells in groups B and C. Liver MDA, osmotic fragility and liver histology have returned to nearly normal in group D. These findings show clearly that high nitrate ingestion can cause pathological changes in liver histology and functions.
The results provide insight into the mechanisms by which amyloid aggregates may cause pathological effects in prion and amyloid diseases.
Gills are exposed to environmental conditions and pollutants, and are also affected by parasites [45], [46], [48], which can cause pathological reactions in this tissue, such as disorganization of the gill filaments, leading to a reduction of the feeding capacity of the mussel [49].
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Other studies, however, have been unable to find definite indications supporting the hypothesis that aluminium plays a causative role in Alzheimer's disease or causes pathological alterations in vivo in the species studied [14 20].
The tumour may be symptomless or may first be apparent from the occurrence of metastases in the lungs, causing spitting up of blood; or in the bones, causing pathological fracture.
That number, however, is likely to grow as pain is redefined not as a symptom but as a disease that "can eventually rewrite the central nervous system, causing pathological changes to the brain and spinal cord, and... greater pain".
Viral infection does not always result in cell death or tissue injury; in fact, most viruses lie dormant in tissue without ever causing pathological effects, or they do so only under other, often environmental, provocations.
A high supplementation of Fe and Mn causes pathological events such as the iron oxides deposition in Parkinson's disease [1, 3].
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