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Adhering to epithelial cells is a crucial step that C. sakazakii must complete to cause pathogenic disease.
The adulterated food products are not only of decreased quality but also may cause pathogenic effects that jeopardize the human health.
Interestingly, a PrP variant, PrP27 30, that lacks the N-terminal transduction domain, but retains the weaker PTD at residues 100 110, retains a low level ability to cause pathogenic conversion of PrPC, suggesting that the second lysine-rich transduction motif may be sufficient in the absence of the N-terminal domain to direct cellular entry.
Therefore, altered expression or dysfunction of CD44 may cause pathogenic phenotypes.
In this hypothesis (H1 + H2), OS and secondarily induced CS cause pathogenic alterations in SCZ.
Of these research groups, only Katz and colleagues [ 20] went on to test the ability of the altered antibodies to cause pathogenic changes in mice.
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To determine if untranslated CAG repeat expansion causes pathogenic effects, we generated transgene constructs containing the EGFP gene with 0, 23 or 200 CAG repeats (designated as CAG0, CAG23 and CAG200, respectively) in the 3' UTR (Fig. 1A).
However, in some circumstances, they are able to enter human bodies from different sources, colonize some organs, multiply within them, and thus exist as opportunistic parasites causing pathogenic effects.
This suggests that genetic alterations in DNA polymerase-γ are not normally deleterious, but that certain conditions such as NRTI treatment may push mitochondrial activity below the clinical threshold, causing pathogenic dysfunction [ 33].
Notably, all Australian H7 viruses were closely related to the strains that caused pathogenic outbreaks in poultry in Australia and thus may identify a potential environmental source of these viruses.
The high prevalence of uORFs in the human transcriptome suggests that intensified search for mutations within 5′ RNA leader regions may reveal a multitude of alterations affecting uORFs, causing pathogenic deregulation of protein expression.
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