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The phrase "cause of unease" is correct and usable in written English.
It can be used to describe a reason or factor that leads to feelings of discomfort or anxiety.
Example: "The sudden changes in the company's management were a cause of unease among the employees."
Alternatives: "source of discomfort" or "reason for anxiety."
Exact(3)
One cause of unease among international legal experts has been the pervasive role played by a team of several dozen American lawyers and investigators.
The other cause of unease is the euro, which threatens either to fall apart or to require yet another German-backed rescue.Germany's state elections are not primarily verdicts on the federal government.
"We know we're a strong force, and that we frighten the government".The second cause of unease is the rise of a militant union, Solidaire Unitaire Démocratique, or SUD.
Similar(57)
I believe that the London audience is well primed for it; 20th-century music is better integrated into mainstream programmes than it is in New York, where hundred-year-old pieces by Schoenberg still cause rumblings of unease".
These are not the cause of their unease, however.
The cause of his unease is his sister, Carolyn.
The cause of this unease is "Ararat," Mr. Egoyan's ninth feature film and arguably his most personal one.
There's no fight, with knives or otherwise, in the original — Transtromer's speaker "slept uneasily" after the call home, but the cause of his unease is unresolved.
But the deeper cause of his unease was something he had seen earlier in the day: two or three houses in Drury Lane with red crosses and "Lord have mercy upon us" painted on their door.
She says that since the Second World War you don't know who your neighbors are, but she doesn't really believe that there's a cause of modern unease.
China is keen to move away as quickly as possible from a dependence on coal-fired electricity generation, whose air pollution is a cause of deep unease at the highest level of government.
More suggestions(18)
cause of discomfort
cause of annoyance
cause of discontent
cause of unrest
cause of preoccupation
cause of trepidation
cause of worry
cause of resentment
cause of dissatisfaction
cause of disquiet
cause of displeasure
cause of insecurity
cause of disappointment
cause of concern
cause of embarrassment
cause of sickness
cause of tension
cause of unhappiness
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com