Suggestions(2)
Exact(7)
It appears that formation of a sticky oxide layer of Fe2O3 during upstream processing is the root cause of this defect.
The presence of ZnO, deliberately formed through the injection of wet HNx into the snout was observed within the arrowhead defect and can be identified as the root cause of this defect.
Disruption of VEGF signaling caused by high CTGF levels could be the cause of this defect.
After determining that the MEKK1mutP cell line exhibits decreased amounts of c-Jun phosphorylation after cytoskeletal disruption, the cause of this defect was investigated.
The cause of this defect remains unknown.
A defect in localization of the protective machinery to kinetochores does not appear to be the cause of this defect.
Similar(53)
According to multiple preclinical and clinical studies, mitochondrial dysfunction (or 'cytopathic hypoxia') is a significant contributor to organ dysfunction and mortality in various forms of critical illness [ 65– 67]; based on the current data, we hypothesize that a suppression of endothelial NO production may be one of the upstream/proximate causes of this defect.
The CFU assays indicate that there are significantly more early progenitors in the TIEG1−/− marrow cultures also eliminating this as a cause of the defect as well.
Therefore, experiments using congenic animals will be essential for determining whether the mutation of Lrd is a definite cause of this laterality defect.
To explore the underlying cause of this proliferation defect, we investigated cell death by measuring the incorporation of the nucleic acid intercalating agent propidium iodide (PI) which is actively excluded from viable cells and retained in membrane-permeant dead cells.
The Reviewing editor and the other reviewers discussed their comments before we reached this decision, and the Reviewing editor has assembled the following comments to help you prepare a revised submission: 1) "We do not know the cause of this repair defect, but one possibility is that allelic DSBs accumulate that have no unbroken sister-chromatid template from which to be repaired.
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