Sentence examples for cause of pathway from inspiring English sources

This tumour did display high nuclear staining of CTNNB1, suggesting that the mutation could be the cause of pathway activation in this sample.

Constitutive KRAS activation by point mutations in codons 12 and 13 of exon 2 has been described as an important cause of EGFR pathway overactivation [7], [8].

In a variety of human malignancies, p16INK4a alterations apparently are a major cause of Rb pathway impairment.

PTEN LOE appears to be the main cause of PI3K pathway alterations in breast cancer and is strongly associated with hormone receptor positivity [ 16], although it is observed also in 8 25 % of TNBC [ 11, 17, 18].

Therefore, more studies are required to understand and assess the cause of these pathways to disabilities.

Causes of alternative pathway dysregulation in dense deposit disease.

We performed screening for the known genetic causes of alternative pathway dysregulation.

By localizing the activation, execution, and characteristics of cell fate effector pathways to individual muscle fibers, we show that the predominant cause of cell death pathway activation in aged rat muscle is mitochondrial abnormalities.

These observations prompted us to hypothesise that oxidative stress is a major cause of the WNT pathway activation in these disease conditions.

In this regard, biological interaction indicates that two risk factors are involved in the same sufficient "cause" of disease, or pathway toward disease (8, 9).

Comparing the epidemiological profiles of these adverse outcomes will guide aetiological research into the causes of and pathways leading to these events.