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We suggest that in a group of unrelated individuals multiple polymorphisms are one cause of modulation of the expression of many genes, dramatically extending the single gene-perturbation paradigm.
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One is from mismatching boundary conditions that are the cause of increasing modulation amplitude when P is increased (see previous analysis on continuous signal functions).
Individual variability of chemokine receptor expression on B cells was as great in recently diagnosed, yet untreated, patients with RA as in those receiving anti-TNF-α therapies, which suggests that TNF-α itself is unlikely to be the cause of receptor modulation.
It is shown that the increase of the gain compression factor causes reduction of modulation bandwidth and improves large-signal properties of quantum dot lasers.
The obtained results can explain the causes of the modulation of energetic electron precipitation fluxes and whistler wave intensity with a time scale of 10too 100 sec in the morning and in the forenoon part of the radiation belts.
Our results can explain the causes of the modulation of energetic electron fluxes and whistler wave intensity with a time scale from 10 to 150 s in the day-side magnetosphere.
As reactive oxygen species (ROS) derived from the mitochondrial electron transport chain (ETC) are the main cause of reperfusion injury, modulation of oxidative phosphorylation (peri-revascularization) may confer benefit.
However, the exact mechanistic cause of the TP modulation by the cytotoxics has not been clearly elucidated and indirect effects via the upregulation of TNF α have been advocated (Sawada et al, 1998, 1999).
Ionotropic receptor channels for glutamate and glycine (GluR5, GluR2 and Glra1) are strongly activated during rhythmic activity such as locomotion [14], whereas some of the metabotropic receptors are know to cause slow modulation of the activity (mGluR1 [86], Gabr2 [87] and Cnr1 [88]).
In addition, a more heuristic scheme, TSA with flexible modulation (TSA-FM), which considers the trade-off of overhead caused by the increase in traffic burst number and the bandwidth loss caused by the degradation of modulation level, is provided to further improve the utilization of radio resources.
In Trichoderma reesei (Hypocrea jecorina) the signals transmitted via the G-protein alpha subunits GNA1 and GNA3 cause considerable modulation of cellulase transcript levels and the extent of this adjustment is dependent on the light status.
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