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Other recent work comparing viral inactivation across the UVC spectrum has shown variations in efficiency are expected, but in general both regions of the spectrum are effective in inactivation, though the precise cause of inactivation may differ20,21.
A bridging-induced conformational change in the catalytic domain of CNA was proposed as the cause of inactivation; however, this hypothesis has not been demonstrated experimentally.
Mutations in helix 3 showed that the new H-bond between T140 and Y195 observed in caspase-3 V266H caspase-3 V266Hse of isactivationot
Pairwise alignment revealed that K747_05620 was missing ten amino acid residues from the C-terminus compared to that of M.Hpy99XVIII, which could be the cause of inactivation of the MTase.
Since DNA methylation results in gene silencing, it has been recognized as a frequent cause of inactivation of tumor suppressor genes and other genes important for tumor development [ 20].
Addition of TAS (150 and 300 n M) to HMEC-1 cells inhibited constitutive and SFN-induced ARE-linked transcriptional response (Fig. 7D), consistent with acetylation as a likely cause of inactivation of nucleus trapped Nrf2.
Similar(53)
Identification of amino acid residues that bind co-transported ions in symporters has been challenging because the inactivation of transport by site-directed mutagenesis is not conclusive with respect to the cause of the inactivation.
This is a way of dealing with the second cause of HIV inactivation.
32 However, there are other models suggesting that DNA methylation is the consequence instead of the cause of gene inactivation.
Some mutational events in more distant distal promoter regions might also be the possible cause of the inactivation of 1Ay gene.
The most common cause of somatic inactivation resulting in MSI identified to date is DNA methylation of the MLH1 gene promoter, specifically in the "C" region.
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