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Incorporation of cFLIPL into the ripoptosome could thus be a cause of Compound A resistance in CLL cells.
Concerns over cardiac side effects are the largest single cause of compound attrition during pharmaceutical drug development.
There is historical precedence that industry can identify and remedy significant causes of attrition; inadequate drug metabolism and pharmacokinetics are no longer the primary cause of compound attrition.
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In addition, cardiac toxicity as a result of drug therapy is one of the main causes of compound attrition during drug development and post-marketing withdrawal.
But the substantial form of a material compound, because it is predicated (accidentally) of the matter of the compound, is the cause of the compound's being the kind of thing that it is.
Dravya, or substance, the substratum that exists independently of all other categories, and the material cause of all compound things produced from it.
These are: Dravya, or substance, the substratum that exists independently of all other categories, and the material cause of all compound things produced from it.
We believe that a conformational change in the MT polymers caused by binding of compound B to the colchicine pocket in the αβ-tubulin dimer may have prevented the association of the proteins with the MT surface.
b Type of compound causing the osmotic stress.
Find the cause of the third or compound, and add this as a fourth class to the three others.
All these trials of compound (564) caused significant neuromuscular toxicity and no objective tumour responses.
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