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Reactive oxygen species (ROS), i.e., the by-products of oxidative metabolism, have emerged as the main proximate cause of ageing.
Yet, while several aspects of daf-2 e1370) daf-2 e1370al function are higher or better preserved with age, state 3 respiration of both WT and daf-2(e1370) mitochondrialshows no such age-specifunction, suggesting tharemitochigheral malfunctior is unlikely a primary cause of ageing.
Being ubiquitous and continuously arising, CNA-induced DNA damage may be the underlying cause of ageing, ageing-related disabilities and the ultimate demise of the organism.
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"What's wrong with finding the cause of aging?" his father asked.
"There's nothing wrong with finding the cause of aging," Jef said.
This, Dr. Sinclair and his colleagues suggest, may be a fundamental cause of aging in mice and probably people, too.
"I thought I had discovered the cause of aging and was going to win the Nobel Prize," Ferrucci said, laughing.
The second problem was the immense difficulty of determining whether any seeming cause of aging was actually causal, or merely a correlative of some other, stealthier process.
Ronald Evans, a biologist at the Salk Institute, said the new report was provocative but did not prove the case that the relocation of sirtuin was a cause of aging.
"We are careful not to say this is the cause of aging, but based on everything we know it's not a bad hypothesis," he said.
"They're really pinning down a cause of aging," says Matthew Longley, a biochemist at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina.
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