Mutations in those receptors have been reported to be the cause of resistance acquisition [ 8].
Though definitive statements cannot be made, mutation accumulation seems like a plausible cause of the observed acquisition of citrate dependence.
The data included age, medical history, mode of acquisition, cause for admission, clinical symptoms, biological and imaging investigations, antibiotic treatments, and evolution after discharge.
These divergent competence vehicles can ultimately cause the acquisition of novel traits such as antibiotic resistance, while they still allow homologous recombination that in turn could facilitate DNA repair and the fixation of beneficial alleles.
To determine whether EndMT could cause an acquisition of MSCs-like phenotype, HAECs were treated with HG to examine the expression of the MSC markers CD44, CD10 and STRO-1.
As shown in Figure 1C all these treatments cause the acquisition of a round-shaped squeezing morphology while control cells maintain an elongated profile and establish contacts with collagen fibers.
Downregulation of PRRX1 caused the acquisition of MET.
Exogenous TM1 expression can reverse transformation, suggesting a direct role for TM1 in transformation (Prasad et al, 1993; Braverman et al, 1996; Shah et al, 2001) and, conversely, enforced downregulation of TM1 causes the acquisition of transformed characteristics (Boyd et al, 1995).
Mouse models that mimicked the deleted genomic locus showed that the main cause of silencing was the acquisition of DNA methylation at the HBA2 promoter.
The most common cause of cephalosporin resistance is acquisition of plasmid encoded blaTEM gene variants that produce β-lactamases with altered degree of cleaving capacity towards 3rd generation cephalosporins.
