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Some papers have reported that excessive endurance training may cause negative remodelling of cardiac structures.
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Furthermore, studies have shown that increased expression of β-MHC in an α-MHC dominant mouse heart causes negative cardiac remodeling in response to numerous stresses (e.g. increases in systolic and diastolic LV dimensions) [35].
On the other hand, ECAC causes negative vessels remodeling resulting in flow restriction and leading to clinical manifestations such as chronic angina or silent ischemia upon a routine stress test [ 18- 28].
The stage of arteriosclerosis progression is frequently associated with remodelling of the arterial wall resulting in dilatation (positive remodelling) in earlier phases, and shrinkage (negative remodelling) of the vessel diameter in the later course of the disease [40].
This coincides with the phase of negative remodelling as previously defined.
In view of the regression equations, positive remodelling (r-lumen increases more than Th-int) exists for the range Th-int/r-IEL<50 Th-int/r-IEL<50 Th-int/r-IEL<50%egative remodirectionor Th-int/r-IEL>50%.
This suggests that negative remodeling occurs early in lesion formation.
Negative remodeling is frequently observed in lesions with intermediate stenosis.
Negative remodeling is commonly observed in stenotic coronary lesions.
It is unknown whether negative remodeling is an early or late event.
This study was designed to elucidate when negative remodeling occurs in the development of coronary stenosis.
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