Sentence examples for cause major effects from inspiring English sources

Phorbol esters, via binding to the PKC C1 domains, cause major effects on mitogenesis by controlling the activity of cyclin cdk complexes and the expression of cdk inhibitors.

Our annotation of human 5' UTR intron sequences has found many candidate polymorphisms which may cause major effects on the expression level of specific proteins through differential splicing of 5' non-coding regions in the final mRNA.

Thus, alterations in p53 signaling in a specific subset of secretory neurons were shown to cause major effects on insulin signaling pathways in critical target organs such as the fat body.

However, it should be noted that hydrogen production by algae during sulfur deprivation is at present a very sensitive process where small changes in physical factors such as light intensity, pH and nutrient composition can cause major effects on the hydrogen production efficiency (Kim et al., 2006a; Kosourov et al., 2003).

Most sequence variations correlated to subspecies pedigrees (japonica vs. indica), so we focused on mutations that putatively cause major effect functional changes.

However, none of these polymorphisms cause major effect polymorphisms.

Josephine also caused major effects to marine interests.

Both a maternal adjustment to the composition of the eggs or to the composition of the brood masses could cause major phenotypic effects in their offspring, potentially through epigenetic effects, such as DNA methylation [ 57].

Current prostate cancer treatments can cause major side effects including urinary incontinence, erectile dysfunction and bowel urgency.

Broad-spectrum inhibitions of MMPs thus interfere with their diverse regulatory roles and thereby cause major side effects 29.

Similar to treatment of hereditary angioedema, a single treatment dose is not expected to cause major side effects including major infections.