Sentence examples for cause loss of functioning from inspiring English sources

CHM mutations cause loss of functioning REP-1, an essential component of an enzyme complex formed with Rab geranylgeranyltransferase. Without functioning REP-1, RABs cannot participate in pathways of intracellular vesicular transport [ 12].

To aid identification of the amino acid changes that cause loss-of-function, computational approaches such as SIFT (Sorting Intolerant From Tolerant) or Mutation Assessor are available.

We note from other species that a defective HD1 homeodomain does not inevitably cause loss-of-function in mating type regulation provided that the HD2 homeodomain in a HD1-HD2 heterodimer continues to function [ 114].

To date, there is not sufficient information to precisely predict the number of mutations in the four sarcoglycans that cause loss-of-function consequences or which result in processing mutants.

Nuclear sex determination can result when CMS is fixed and only restorers segregate (Klaas and Olson 2006), or when nuclear mutations cause loss-of-function (LOF) in the pollen development pathway irrespective of cytoplasmic genes (Bailey and Delph 2007).

In fact, the average human family carries hundreds of mutations that cause loss of function.

Temporomandibular joint ankylosis is a joint disorder due to bone or fibrous adhesion of the joint components that cause loss of function.

Adoptive transfer of perforin-deficient SCILs did not cause loss of function in hosts at any time point.

Mutations in these CCM loci cause loss of function of these proteins and result in CCM [7] [16], [17], [23].

This mutation they found was different from the one we identified but was also predicted to cause loss of function.

However, in cancer cells, p53 activity is frequently compromised, and the majority of the known p53 mutations cause loss of function and impair its transcriptional activity to varying extents [67].