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Fibrosis, regardless of the cause, is characterized by extracellular matrix deposition, of which collagen type I is the major constituent.
Reye syndrome, a disorder of unknown cause, is characterized by acute encephalopathy and fatty degeneration of the liver and it is usually characterized by a history of preceding viral illness or the use of aspirin during viral infections [ 10].
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ALS, a neurodegenerative disease with unknown cause and no cure, is characterized by the death and dysfunction of motor neurons in the cerebral cortex, BS and SC (Boillee et al, 2006a; Nayak et al, 2006).
Sarcoidosis is a multisystem disease of undetermined cause which is characterized by the widespread presence of non-caseating granuloma [ 1].
Obesity is a pathology with multifactorial causes that is characterized by an increase in fat body mass and is linked to a significant increase in morbidity and mortality.
Special-cause variation is characterized by deviations from the natural behavior of the system, such as might be seen following an intervention.
Alzheimer's disease (AD) is a neurodegenerative disease involving impairment of cognitive function with both genetic and nongenetic causes, which is characterized by a loss of basal forebrain cholinergic neurons and reduced level of neurotransmitter acetylcholine (ACh) in hippocampal and cortical levels, leading to severe memory and learning deficits [ 1].
Osteoarthritis (OA), the commonest form of arthritis and a major cause of morbidity, is characterized by progressive degeneration of the articular cartilage.
Glaucoma, a leading cause of blindness, is characterized by progressive retinal ganglion cell loss and excavation of the optic nerve head.
Mutations in the SHH gene in humans cause holoprosencephaly, which is characterized by abnormal forebrain and facial development, including cleft palate [ 34].
Regardless of the causes, liver fibrosis is characterized by increased extracellular matrix forming hepatic scars [ 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com