IN 1988 polio caused huge concern: the disease, which leaves one victim in every 200 paralysed, was prevalent in more than 125 countries which together counted 350,000 cases annually.
Lansley has caused huge concern among coalition partners by failing to win over public opinion, or any major health or medical organisation, by insisting on a big bang approach to change in the NHS.
Hunt, whose handling of the dispute caused huge concern in the NHS and medical establishment, may now face questions over why he took so long to, in effect, stage a climbdown.
The Gambian government's treatment of journalists and opposition parties has also caused huge concern among human rights groups.
"Ad blockers are causing huge concern for advertisers and publishers and media owners," says WVM's Sean Randles.
She went on: "They present an aerial occupation, almost a form of collective punishment, that causes huge concern and distress to people living in those communities.
Until now, most of the wrasse used in salmon cages have been taken from the wild, which has caused huge concern among environmental groups.
Mr Burderer's further admission that assisting tax evasion was common practice in Switzerland has caused huge concern among the Swiss banking community, according to the BBC's Switzerland correspondent, Imogen Foulkes.
The plight of the bee, in Britain and elsewhere, has been a constant headline generator as their decline attributed to multiple factors like climate change, disease, pesticides, parasites has caused huge concern because bees are excellent pollinators.
