The expression of APC may be down-regulated in cancer cells due to promoter methylation (Tsuchiya et al., 2000); however, RT PCR analysis indicated that this was not the cause for the differential APC protein abundance in these three lines.
Therefore, the climate constitutes probably merely the ultimate cause for the differential species distribution.
Therefore, the translocation step is not rate limiting and is thus not the cause for the differential response.
In the present study, we examine the underlying cause for the differential cell death phenotype between 129B6 and DBA/2J mice heterozygous for the mutant Bax allele.
It is also reasonable to argue that decreased Fe toxicity upon - Fe might have been the cause for the differential regulation of these genes.
We conclude, therefore, that the dissipation of DNA helical stress at the chromosomal ends is the most likely cause for the differential response of chromosomal flanking genes reported here.
To assess other possible causes for the differential behaviour of the distinct caspase-10 isoforms, their stability was measured using the protein synthesis inhibitor cycloheximide (CHX).
Studies show that there may be a differential effect of structured guideline implementation on the quality of provider performance and patient outcome, while the underlying causes for these differential effects are neither obvious nor easily explainable.
Additional causes for the differential response to drought and the underlying gene expression may involve changes in gene regulation by structural variation [ 38], epigenetic modifications of chromatin state [ 39], transposable elements activity [ 40], or a combination of more than one mechanism.
Reverse Causal Analysis (RCA) of experimental data evaluates each node in the KAM as a hypothesis, a potential cause for observed differential measurements in an experiment.
