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Identical behavior of these mutants in CD and fluorescence measurements as well as limited proteolysis assays ruled out the possibility of global conformational changes induced upon mutagenesis as the cause for the variations in the kinetic and binding parameters.
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Failure data from field provide useful information to assess if the changes in product reliability variations are significant or not and to identify the cause for the variation.
Terrain complexity has been identified as a cause for the variation in DTM accuracy across landscapes [37].
Geogenic sources are one of the cause for the variation in chemical composition of groundwater which changes with space and time (Madhavan and Subramanian 2007; Zahid et al. 2008; Vikas et al. 2009; Gunduz et al. 2009; Mamatha and Rao 2009; Brindha et al. 2011).
Terrain complexity has been identified as a cause for the variation in DTM accuracy across landscapes [ 37].
The range of criteria used to diagnose PCOS is well recognized as a cause for the variation in morbidity associated with this syndrome.
The reason for this variation is poorly understood but it may be the effect of genotype [ 2], breed or strain, which are thought to be the cause for the variation in the neuropathology in classical scrapie [ 18- 20].
Even when we consider the existence of true biological variation in the cells by transcriptional bursting (Chubb et al., 2006; Raj et al., 2006) or heterogeneity of the cultured cells, it is obvious that variation of the sequencing depth is a contributing cause for the variation of sensitivity; e.g. experiments at shallow sequencing depth could detect a smaller number of features (Fig. 1A).
However, the cause for these variations is not clearly understood.
As the clinical examination and the BAER test showed no hearing impairments in any dogs participating in this study, the cause for these variations is unclear.
The most likely cause for this variation is the different properties of the aggregate used in each study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com