As the signature of positive selection is less profound in Europeans compared to East Asians, but AGA prevalence is higher in Europeans, it seems likely that the AGA causative variant and the cause for positive selection are distinct from each other.
First, use of hospital-based control in this study for potential cause of selection bias.
A strong iHS signature near the end of chromosome 6 was also detected, as previously observed in other populations8,9,10,13,23, for which the cause of selection is unknown.
Although the precise cause for positive selection of sex-associated genes in Neurospora is unknown, we speculate that it may be driven by natural or sexual selection.
Inequalities in sports cardiology screening should not be a cause for natural selection or contribute to the possibility of later complications of aortic/atrial enlargement and arrhythmias.
Thus, Matthen and Ariew (2002, 56) write, "Unlike vernacular [individual] fitness, predictive [trait] fitness is not a cause of selection, or of evolution for that matter….
KVG performed the phylogenetic analysis, detection of positive selection, analysis of protein evolution, suggested the causes for positive selection events.
However, further clarification of the pathway for nuclear import or retention and the amino acid sites involved in both partners would be required in order to fully assess the impact and possible causes for positive selection in this region.
In contrast, a phylogenetic tree using amino acid sequences at substrate recognition sites did not cluster the CYP2D6 and CYP2D8 genes, suggesting that the functional constraint on substrate specificity is one of the causes for purifying selection at the substrate recognition sites.
Finally, we used data on about 13,000 SNPs to compare allele frequency distributions between the HWS and LWS lines to investigate if we could detect any molecular footprints in the form of selective sweeps caused by selection for body-weight.
Conversely, the trend toward increasing compactness for highly expressed genes could be caused by selection for minimization of energy and time expenditure during transcription and splicing and for increased fidelity of transcription, splicing, and/or translation that is likely to be particularly critical for highly expressed genes.
