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The findings in this study are in accord with a common structural cause for the destabilization of the rNTP-bound post-translocation state and of the pre-translocation state after rNMP incorporation.
Pakistan badly needs that aid because poverty is one of the principle causes of destabilization and terrorism, according to many experts on the region.
Our method consists of (i) determining the three-dimensional structure of an antigen, (ii) identifying protective epitopes, (iii) generation of an antigen fragment that contains the protective epitope, and (iv) rational design to compensate for destabilization caused by truncation.
For instance, lipophilic or surface-active lipophilic compounds may cause a destabilization of the eye tear film leading to epithelial damage of the conjunctiva (Wolkoff et al. 2003).
Empowerment through information can cause temporary destabilization and hardship, as we saw with the Arab Spring.
In addition, invasion into a resident system far from equilibrium characterized by population oscillations is likely to cause further destabilization.
Moreover, all 2′-SCF3-modified nucleosides cause thermodynamic destabilization when they reside in double helices.
MMP-9 and gelatinase activity have been shown to cause a destabilization of advanced plaques in mouse models, and in humans MMP-9 is a biomarker for risk of acute coronary events (Gough et al. 2006; Hlatky et al. 2007).
The reduction of the synaptic strength below a certain threshold is postulated to cause synaptic destabilization and acute schizophrenic symptoms.
Prediction of SNPs that cause a destabilization of the protein structure was made using CUPSAT (Parthiban et al. 2006).
It has proven difficult to pinpoint a particular purification step as the one responsible for destabilization.
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