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Depletion of alveolar macrophages has been shown to cause exacerbation of respiratory mycoplasmosis in the M. pulmonis-resistant C57BL/6 mouse strain, although interestingly not in the M. pulmonis-susceptible strain C3H [44], [44].
In this review we considered the evidence that specific indoor environmental exposures might cause exacerbation of asthma.
It would be important in the future to correlate the magnitudes and characteristics of the immune responses with the microbial species that cause exacerbation.
Current treatments for opioid addiction cannot reverse these neurobiological alterations, and can even cause exacerbation in some cases, resulting in high relapse rate after detoxification [ 18].
Studies from several different laboratories have now concluded that the specific COX-2 inhibitors rofecoxib and celecoxib do not cross-react with aspirin and NSAIDs to cause exacerbation of asthma or naso-ocular symptoms in patients with AERD.
The studies previously cited by the IOM (2000), in conjunction with Atkinson et al. (2006) and Pongracic et al. (2010), demonstrate that outdoor fungal exposures cause exacerbation of asthma in sensitized individuals.
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Topical prostaglandin analogues used to treat glaucoma are known to cause exacerbations of uveitis [1, 2].
Viruses are well known to cause exacerbations of asthma and chronic obstructive pulmonary disease, but the association between influenza virus and cardiovascular disease is less clear.
Exposure of individuals with established allergic disease to high levels of sensitizing allergens causes exacerbation of symptoms and worsening of the underlying inflammatory process.
Conclusions: These data reveal that dental procedures, specifically third molar surgery, can significantly alter the course of eating disorders, causing exacerbation or relapse.
Disruption of these mechanisms may not only give rise to several autophagy-related disease, but also it can occur as the result of intracellular changes induced during disease pathogenesis causing exacerbation of the disease.
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