Vadimezan (ASA404, DMXAA) belongs to the class of small molecule vascular disrupting agents (VDA) that cause disruption of established tumor vessels and subsequent tumor hemorrhagic necrosis.
This model's success enables further study into causal pathways by which endocrine-disrupting and endocrine-mimicking substances may directly cause disruption of normal human urethral development or hypospadias.
Increasing evidence shows that wild populations of both estuarine and freshwater fish are being exposed to endocrine-disrupting chemicals (EDCs) in concentrations sufficient to cause disruption of their reproductive physiology [reviewed by Jobling and Tyler (2003)].
Several endocrine disrupting chemicals and their interactions with AR may cause disruption of normal endocrine function as well as interfere with metabolic homeostasis, reproduction, developmental and behavioral functions.
But he said officials were still concerned that a Congressional inquiry could cause "disruption of our initial witness interviews, the delay and disruption of our document collection, and the tainting of any future criminal prosecutorial action because of Congressional grants of immunity to witnesses".
Microcystin-LR (MC-LR) is commonly characterized as a hepatotoxin, which can cause disruption of keratin filaments.
The antibody manipulation and exposure to stress conditions during the processes of conjugation, lyophilization and labeling, can cause disruption of the native structure of the protein.
It is well established that pharmaceutical processing can cause disruption of the crystal structure, leading to generation of amorphous content in crystalline materials.
This contrasts with the more common mechanism of perilunate injury (Mayfield's classification), where the forces cause disruption of the ligaments from the radial side, resulting in a dorsal intercalated segment instability (DISI) pattern [10].
If a similar process were to occur in RES one could speculate that this could cause disruption of sympathetic tone of the ear vessels resulting in vasodilation and reddening of the ear.
Intrinsic apoptotic signaling, activated by cell damage, is promoted by GSK3 by facilitation of signals that cause disruption of mitochondria and by regulation of transcription factors that control the expression of anti- or pro-apoptotic proteins.
