Sentence examples for cause destabilisation from inspiring English sources

The prime minister cited worldwide evidence of uncontrolled migration flows which cause destabilisation but insisted he wasn't about to dictate to others.

The large-scale plasma structures convect across the polar region and cause destabilisation of the plasma, leading to the generation of small-scale irregularities causing scintillation (Valladares et al. 1994 and the references therein).

In addition, ROS cause destabilisation of lysosomes, presumably leading to cytosolic translocation of various proteases (Neuzil et al, 1999, 2002).

In this study, we address this possibility and describe a new class of sulphoxythiocarbamate small-molecule inhibitors of HSP90 that, by virtue of their sulphhydryl reactivity, target HSP90 to cause destabilisation of its client oncoproteins and inhibit cell proliferation.

Which factors cause destabilisation of the native structure and the increase in the steady-state concentration of partially folded conformers in vitro and in vivo is now becoming clear for at least some proteins involved in amyloid disorders [108].

Further investigation showed that EL102 inhibited tubulin polymerisation and caused destabilisation of the microtubules in DU145 prostate cancer cells.

By virtue of their cysteine reactivity, sulphoxythiocarbamates target HSP90, causing destabilisation of its client oncoproteins and inhibiting cell proliferation.

Their downregulation induces deregulated expression and degradation of E-cadherin and β-catenin causing destabilisation of the cadherin/catenin complex, and altered the expression of Wnt-related genes.

Finally patients typically accrue increasing medications, with management often comprising addition of new medication, with existing (or previously added) ones seldom discontinued for fear of causing destabilisation.

This work demonstrated that the mutation caused destabilisation of the uncharged mt-tRNAval, such that the transmitochondrial cybrid line carrying the mutation had severely depleted steady state levels of mt-tRNAval.

We still await the detail of these proposals but a move to local bargaining has the potential to cause massive destabilisation".