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The authors acknowledged that gene gun insertion can cause "deletion and extensive scrambling of inserted and chromosomal DNA".
Several rare autosomal-recessive mutations in PERK, which cause deletion of the C-terminus or kinases of no or low activity were described in members of inbred families diagnosed with the Wolcott-Rallison syndrome that develop diabetes [59].
Since the discovery of the first genetic cause (deletion of chromosome 17p13.3), six additional genes have been found to be responsible for agyria pachygyria.
In mice carrying Baf57 ΔR and expressing FlpoER1, TAM injection therefore would induce nuclear translocation of FlpoER1 to cause deletion of the gene-trap cassette and hence activation of the Baf57 ΔR.
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Since, repetitive elements are numerous in the human genome; consequently SSA could mediate large-scale rearrangements that cause deletions of sequences located between the repeats.
Recombination may also cause deletions of ISs [ 71].
Thus, replication errors in longer (CA) stretches produce both insertions and deletions, whereas shorter stretches cause deletions only (16, 34).
Alu elements not only cause deletions, but also seem to contribute to the formation of segmental duplications.
More than 110 mutations have been identified that effect GALC mRNA processing or cause deletions, frameshifts and missense mutations.
Specific mutations that cause deletions, frameshift mutations, premature stop codons or splice site abnormalities that impede VDR expression or binding activity, effectively suppress key VDR actions [20].
Arsenic has been known to cause deletions in cell lines but in the absence of animal models, it is impossible to undertake an in-vivo study.
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