The other toxic gases that lagoons emit, including hydrogen sulfide, methane and carbon dioxide, can also cause deleterious environment and health impacts.
High temperatures cause deleterious changes in hydrated products of Portland cement, compromising its physical properties, mainly, the compressive strength.
Large volume infusion for the achievement of profound hypothermia may cause deleterious effects of increased ICP and is not warranted.
Prolonged exposure to heavy metals such as cadmium, copper, lead, nickel, and zinc can cause deleterious health effects in humans (Harrison and Laxen 1981).
Atherogenic diet (AD) and high fat diet (HFD) cause deleterious effect on bone micro-architecture and this phenomenon prompts aortic calcification.
In some cases, supraphysiologically high loadings are used to achieve therapeutic local concentrations, but uncontrolled release can then cause deleterious off-target side effects.
Their activity in terms of insertions and/or chromosomal rearrangements can cause deleterious mutations (Crow and Simmons 1983; Mackay 1986) including human genetic diseases (Wallace et al. 1991; Holmes et al. 1994).
Collectively, our data provided convincing evidence that the tool drug for experimental diabetes STZ may itself cause deleterious cardiac contractile dysfunction via an oxidative stress and p38 MAP kinase-dependent mechanism.
Values of estimated daily intake per meal size of seafood for humans in some species were higher than the accepted tolerable intake provided by Joint FAO/WHO Expert Committee on Food Additive (JECFA 2010), suggesting that levels of assumed exposure are likely to cause deleterious effect during lifetime in humans.
It is also recognized that artificial selection can cause deleterious mutations to accumulate in domesticated populations for various reasons, including inbreeding and the hitchhiking of deleterious genes along with those under intense artificial selection (e.g., Lu et al. 2006; Cruz et al. 2008).
Integration of these techniques with specifically designed animal models for final validation should lay the foundations for the development of new inhibitors that specifically target disease-related MMPs and/or their upstream effectors that cause deleterious effects in disease, while sparing MMP functions that are protective.
