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If XDR-TB became widespread, its severity and the difficulty of case management and infection control could cause considerable challenges for global public health.
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However, the complexity of the ubiquitin system causes considerable challenges for high-throughput drug discovery because of extensive structural similarities.
The increasing number of individuals with cancer receiving potentially life-threatening treatments which have significant side-effects causes a considerable challenge for acute hospital services.
EIEE can cause considerable hardship for families and the identification of the underlying aetiology for EIEE continues to present a significant clinical challenge.
He could cause considerable embarrassment for his longtime patrons.
BA also warned the strikes would cause "considerable uncertainty" for customers booked to fly into UK airports on Wednesday.
They also cause considerable disruption for patients and carers.
In particular, shallow landslides cause considerable losses of productive soil and represent a challenge for risk management in such systems (Heaphy et al. 2014).
But industry analysts say that the deal poses some considerable challenges for Hewlett-Packard.
Zumba's meteoric rise has also created considerable challenges for the company.
Global change poses considerable challenges for ecosystems and their managers.
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