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Hsf1 activation or TOR inhibition cause clearance of aggregation-prone proteins in higher organisms [80] [82], but it remains unknown if potential connections between Hsf1 activation and mTOR exist and contribute to these phenotypes.
Furthermore, study researchers found that the vaccine-specific T cells exhibited a killing function, and could migrate to and stay in the liver and cause clearance of target cells without any evidence of liver injury.
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Rapamycin also causes clearance of aggregation-prone proteins [ 110].
These results indicate that niclosamide does not cause the clearance of other large complexes/organelles like ribosomes or mitochondria.
However, in children carrying low density infections that do not cause illness, clearance of parasitaemia may not be advantageous as it could result in the loss of cross-protective immunity against similar parasite genotypes (premunition) and consequently increase the risk of subsequent malaria [17], [18].
Treatment with corticosteroids has been shown in bronchoalveolar macrophages from both mice [ 36] and humans [ 31] to cause impaired clearance and killing of Aspergillus fumigatus conidia, and has also been associated with enhanced growth of Aspergillus species [ 37].
Current recommendations call for maximizing the supportive care measures including adequate leucovorin dosage, urinary alkalinization, avoidance of medications that impair MTX excretion, and clinical evaluation for pleural effusions or ascites which can accumulate MTX and cause delayed clearance.
Sampei et al. identified a positive charge patch on an anti-FIXa antibody that was implicated in causing fast clearance.
The problems were exacerbated with the construction of St Katharine Docks (1827) and the central London railway termini (1840 1875) that caused the clearance of former slums and rookeries, with many of the displaced people moving into the East End.
This is partially caused by clearance by receptors recognizing incompletely glycosylated proteins.
Early during the infectious process, asymptomatic individuals show strong inflammatory response, which causes virus clearance.
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