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A lack of informed decision making can have detrimental effects to patients, cause attrition of potentially successful development programs, or induce substantial financial losses.
They increase health expenditure, cause attrition of future labour and productivity, and erode investments in human and physical capital formation [ 32].
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In addition to these quantities, the mechanical agitation of the feeder can cause attrition or over-lubrication of the powder blend or granulation flowing through the device.
Drug toxicity is a leading cause of attrition of candidate drugs during drug development as well as of withdrawal of drugs post-licensing due to adverse drug reactions in man.
This would be costly and would likely cause considerable attrition of participants.
The initial idea of the CHW assumed the existence of a pool of willing volunteers, but lack of payment has emerged as an important cause of attrition of CHWs in many programmes [ 16, 26].
Since efficacy in one or more preclinical animal tumor models generally provides the rationale in support of a new anti-neoplastic drug's probable benefit in humans, is the primary modifiable cause of attrition of new drugs a consequence of poor prediction of human activity/potency from animal models?
The main causes of attrition of health workers in 2004 were death and resignation of workers from the health service [ 16].
In science, stereotype threat may contribute to the leaky pipeline, causing the attrition of women from science-related majors.
The leading causes of attrition of new drugs are generally cited as being unpredictable toxicities and lack of efficacy, the early identification of which are primary goals for preclinical animal models.
This resulted in occlusal interference, which caused the attrition of the tip of the cusp and the opposing maxillary incisor, and displacement of the mandibular central incisor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com