Exact(3)
These mutations usually result in a completely different translation from the original, and are also very likely to cause a stop codon to be read, which truncates the creation of the protein.
rs76179099, which maps to the first nucleotide binding domain of the protein, would cause a stop codon to be inserted in this position and may cause the premature translational termination of this ABC protein.
Point mutations may cause a stop codon shift, when the existing stop codon is destroyed and gene length is increased, a start codon drift, or appearance of a premature stop codon.
Similar(57)
9.31pm BST Argentina 27 - USA - 36, 5 34, 2nd Quarter Gutierrez finally causes a stop in the action by fouling LeBron James as he's making a basket.
This mutation causes a stop codon at the tyrosine at position 445 of this 1998-amino acid long protein (Figure 4E).
Coevolutionary gene clusters were identified using transcripts that show NSC variants, including SNVs causing a stop gain or stop loss in at least one strain compared to the reference BN genome.
A C to T substitution at nucleotide position 943 caused a stop codon resulted in the formation of a truncation of the VelA protein from 562 to 315 amino acids long.
Only four strains exhibit any variants in sad-2, including two strains, FGSC 821 and FGSC 3921, which feature a nonsense mutation that causes a stop codon at amino acid position 208 out of 1098.
As expected, nonsense variants, which cause a premature stop, were most likely to be associated with diseases with 2.77% probability.
Although lf1132 contains two new insertions and 6 new single substitutions, it can still be translated to produce a protein since these mutations do not cause a premature stop codon (Fig. 3D).
These insertions and single-base substitutions do not locate in the zinc-finger domain and CCT domain, also do not cause a premature stop codon in lf1132 (Fig. 3A).
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