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"Look at any disaster - unless it's caused by a terrorist bomb, it's normally down to a number of factors which, taken individually, would not cause a major problem".
No great harm was done on this occasion but the phenomenon of errors being republished over and over does cause a major problem for citizens in our democracy.
In an open letter on Thursday, they tell King that the global drive to reduce carbon emissions could mean billions of pounds of fossil fuel reserves will rapidly lose value and cause a "major problem" for institutional investors and pension funds.
Rodent plagues cause a major problem for agriculture in many temperate regions, and immunocontraception offers a new method to control fertility in these and other pest vertebrates.
Individual differences among patients and even in different areas of the same tumor in one patient may cause a major problem with PDT: dose calculation during application of the light.
Southern California Edison is finally shutting down the oddly-troubled San Onofre nuclear power plant, with outstanding questions about who will pay the enormous decommissioning costs, and of course the matter of making sure that the missing reactors, offline since the beginning of 2012, don't cause a major problem of energy supply in the hot summer months.
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"When there's an economic problem in the region, Argentines stop coming and that causes a major problem," said Mónica Lozano, the hot springs specialist for the Uruguayan Ministry of Tourism.
It might seem like a very oh-Florida thing to have a competition to hunt giant snakes, but they are causing a major problem in the 1.5m-acre Everglades national park, a protected land.
Excess fluid loss due to degradation of additives of drilling fluids causes a major problem in real-time drilling.
While that's never caused a major problem, you can imagine how it easily could, and undoubtedly has, for a lot of people.
Dumped and abandoned horses are putting lives at risk, causing a major problem for police and costing councils in south Wales thousands of pounds.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com