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In damaged and diseased CE, any acute or accelerated loss of corneal endothelial cells (CEnCs) significant enough to cause a functional imbalance, will result in a leakier CE layer and weakened pump function, hindering regulation of corneal hydration7,8,9.
We hypothesize that an interictal hypoactivity of monaminergic pathways may cause a functional disconnection of the thalamus in migraine leading to an abnormal intracortical short-range lateral inhibition that could contribute to the habituation deficit observed during stimulus repetition.
We hypothesized that an interictal hypoactivity of monaminergic pathways may cause a functional disconnection of the thalamus in migraine leading to an abnormal intracortical short-range lateral inhibition, which could contribute to the habituation deficit observed during stimulus repetition.
We have proposed previously that hypofunctioning serotoninergic projections to thalamus and cortex might cause a functional disconnection of the thalamus leading to increased gamma band oscillations in the cortex, as in other thalamocortical dysrhythmias, and to reduced cortical habituation [2, 7].
Panther estimates the likelihood of a particular nonsynonymous (amino acid-changing) coding SNP to cause a functional impact on the protein.
How can it therefore reach a sufficient heteroplasmy level to cause a functional defect?
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Lineage-specific transitions of this kind could alter the conformational ensemble accessible to the same protein in different species, causing a functional change, even if the predominant function remains conserved.
On the other hand, within these contextual components (field, tenor and mode) there is a systemic variation in the relative prominence of different options, which causes a functional variation in the language, i.e. register.
Warfarin causes a functional deficit of factors II, VII, IX, and X, as well as proteins C and S. Plasma should only be used for the reversal of warfarin if there is evidence of severe bleeding or intracranial haemorrhage.
Although these changes may have caused a functional default in the respiratory chain inducing oxidative stress, the expression of SOD2, a gene coding for a protein involved in superoxide detoxification, had not significantly decreased even at T48.
The persistence of tropical coral reefs is threatened by rapidly increasing climate warming, causing a functional breakdown of the obligate symbiosis between corals and their algal photosymbionts (Symbiodinium) through a process known as coral bleaching.
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