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Disruption of growth of the tongue and/or mandible can therefore secondarily cause a cleft secondary palate.
We took advantage of a Gad1 conditional allele to demonstrate that an early neural precursor specific knockout of Gad1 was sufficient to cause a cleft palate phenotype in mutant embryos.
Consistent with these observations our CNS specific knockout of Gad1 in neural precursor cells showed the loss of Gad1 function specifically within the CNS was sufficient to cause a cleft palate and body wall phenotype.
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The paralog Zfhx1a (a.k.a. Zeb1) when knocked out in mice causes a cleft palate phenotype with 100% penetrance [59], [60].
In contrast, mutations affecting brain patterning affect not only GnRH cell development but also cause a variety of associated phenotypes: cleft lip, cleft palate, high arched palate and other midline defects (reviewed in Silveira et al., 2010).
We hypothesize that some of the morphologic deformities associated with cleft lip may cause a failure of mesenchymal reinforcement of the facial processes at a critical time in development.
Subsequent binding of pyrimidine in the active site cleft is thought to cause a further 20° rotation thereby leading to a fully closed conformation [12].
These different nasalance scores of the same vowels seem to cause an ethnic difference between Vietnamese and Korean cleft palate children.
Specific mutations in IRF6 cause Van der Woude syndrome, which causes a specific form of cleft lip and palate (Kondo et al. 2002).
Freeman Sheldon syndrome (Ng et al., 2009), inherited mutations for breast and ovarian cancer (Walsh et al., 2010) and a single non-sense mutation that causes a syndromic form of cleft palate (Johnston et al., 2010).
She does not have a cleft palate.
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