Variation in dispersal within a population is most probably due to the interaction between genetic and environmental causes (Dingle 1991) making it difficult to attribute a causative role for either.
The effects of FAST-1 overexpression on CTCF, H3K9ac and H3K9me3 at the FXN 5′UTR locus indicated a potential causative role for FAST-1 in FRDA.
These data suggest a possible causative role for MyoD in the observed upregulation of MHC IIB in the unweighted soleus muscle.
Recent studies provide strong evidence for a causative role for traffic-related air pollution on morbidity outcomes as well as premature death (Health Effects Institute, 2009; Levy et al., 2010; von Stackelberg et al., 2013).
Animal models, epidemiological data, and small clinical trials have favored a causative role for hyperuricemia in hypertension but more studies are necessary to elucidate putative mechanisms, population susceptibility, and potential for urate-lowering therapies (ULT) to decrease blood pressure (BP).
While a growing body of evidence from experimental models supports a role for B cells in regulating or suppressing immune responses, a causative role for B cells in clinical transplantation tolerance has yet to be proven.
Moreover, in the majority of our cases (71%) epilepsy preceded MA and this finding is not consistent with a causative role for MA in epilepsy, as previously suggested [14].
Although some epidemiological studies show a significant correlation between cadmium exposure and occurrence of disease conditions in human populations, a causative role for cadmium as the factor behind these effects remains yet to be shown.
This association does not per se indicate a causative role for ING2 deficiency in human male infertility.
Another study [69] was consistent with a causative role for mtDNA variations in phenotypic differences (egg size, fecundity, cold resistance and starvation resistance), among fly line.
Elevated CRP concentration in the blood is a well recognized risk factor for future cardiovascular disease, although some studies argue against a causative role for CRP [45], [46].
