The combined investigations using histopathology, molecularpathological techniques and immunohistochemical methods were able to reveal the causative agents of death.
The resulting increased intestinal permeability is highly correlated with mortality within 24 hr after injury and is very likely to be one of the main causative factors of death.
There is evidence that Ar. subalbatus employs anti-oxidant molecules for both reactive oxygen species (ROS) production and for recuperative metabolism following an oxidative burst, and it has been hypothesized that ROI and RNI generated during melanin biosynthesis are the causative agents of death to sequestered pathogens [ 48].
The most common cause of death was sepsis, with staphylococcus being the most frequent causative organism [ 10].
When outbreaks of emerging infectious diseases occur, pathology can often identify the cause of death, but may not be able to identify the causative agent.
In many cases, cancer recurrence will clearly be the cause of death, but VTE, both evident and silent, may be causative, particularly in cases in which death occurs in the absence of obvious disease recurrence.
However drug treatment, chronicity and cause of death, may confound interpretation and such studies cannot easily probe causative mechanisms.
Pseudomonas aeruginosa is a common causative pathogen in nosocomial pneumonia and lower respiratory tract infections are the leading cause of death from nosocomial infections [11].
Moreover, the significance and impact of BBB dysfunction in GA-I as causative of neuronal death is still poorly understood.
However, identification of the main causative factors is extremely difficult because these events involve a complicated interplay between the physiological condition of bivalves and environmental factors, so the cause of death can rarely be explained by a single factor.
