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Several suggested causative links have been described, but the pathologic mechanism remains unclear.
Increasing evidence has established causative links between obesity, chronic inflammation and insulin resistance; the core pathophysiological feature in type 2 diabetes mellitus.
There is mounting evidence demonstrating causative links between hyperglycemia, oxidative stress, and insulin resistance, the core pathophysiological features of type 2 diabetes mellitus.
Using seven different hypotheses concerning the causative links among language competency, communication with non-Hispanics, psychological health and academic performance, researchers found that high ratings in a category corresponded with high ratings in all the others.
Whereas the association of chronic neurodegeneration and inflammation is well established, the causative links between these events is debated.
We addressed causative links between the biochemical, pathological and inflammatory disorders in a mouse model of this disease.
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The associations reported in this paper do not prove or imply a causative link; and paradoxically agents that might cause gastrointestinal haemorrhage were not associated with greater degrees of iron deficiency.
This led the IARC to classify shift work in category two on the list of causes of cancer, that is, as a 'probable causative link'.
Altogether, Down syndrome may be considered as a cause of both asthma and acute leukaemia and drawing a causative link from asthma to acute leukaemia in this setting seems a raw conclusion.
More importantly, these animal studies have been supported by concurrent clinical data showing that blood-brain barrier disruption (BBBD) causes seizures in human subjects [4] and that BBBD has a causative link with post-traumatic epilepsy [3].
Of course, the absence of evidence of a causative link is not evidence of its absence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com