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Finally, in light of advancing evidence of the causative interplay between impaired limb skeletal muscle oxidative metabolism and PAH in other populations (Tolle et al, 2008a), it is an intriguing possibility that mitochondrial dysfunction in both limb muscle and pulmonary vasculature in this individual may be responsible for her pulmonary vascular pathophenotype.
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In particular, while the Mendelian diseases are due to causative rare mutations in specific genes (causative gene) and are inherited according to Mendel's laws, multifactorial diseases are caused by an interplay between several genetic and environmental triggering factors [ 2, 4].
Case fatality rates are not constant; they can vary between populations and over time, depending on the interplay between the causative agent of disease, the host, and the environment as well as available treatments and quality of patient care.
The emergence of coral disease occurs from a complex interplay between the host, causative agent and environment [23].
However, identification of the main causative factors is extremely difficult because these events involve a complicated interplay between the physiological condition of bivalves and environmental factors, so the cause of death can rarely be explained by a single factor.
An interplay between both susceptibility genes and still unknown environmental factors is considered to be causative of the disease.
The interplay between them can be beautiful.
The interplay between the duo has a larky, pantomime suggestiveness.
There's a lot of interplay between these".
The interplay between the two is like musical telepathy.
Lovely interplay between Mrs Patmore and Mrs Hughes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com