Indeed, the presence of AChE in a variety of lymphoid and reticular cell types [ 68] and particularly in follicular dendritic cells of the germinal centers [ 69], the splenic cells in which prions might actively amplify, makes plausible a causative AChE-PrP interaction in prion pathogenesis.
Without understanding the system's nature and components (anatomy), environment and structures (CES), and the mechanism that explains their causative and probabilistic interactions, fraud may not be deterred or detected on time.
Notably, pure cases of thiamine deficiency, unaccompanied by chronic and excessive alcohol consumption (such as in cases of malnutrition), show a low rate of progression to KS [ 29], giving credence to the idea that an interaction of causative factors is responsible for the lasting cognitive deficits seen in alcohol-related disorders.
However, it may be more likely to find an apparent local interaction caused by a haplotype effect when each SNP is in LD with a single causative variant, but LD between SNPs is low.
The study analysed backpack-related back pain in school children by investigating the possibility of multiple interactions among causative factors, which may be responsible for the non-conclusive findings on the issue.
Recent studies have linked the composition of these microbial communities with alterations in the host's health, behavior, and development, yet the causative mediators of host microbiota interactions remain poorly understood.
Many psychiatric disorders are multifactorial, reflecting longitudinal and complex interactions of causative agents, including genetic and environmental factors.
However, determination of causative relations or possible interactions between the observed changes requires further investigations.
Even in model organisms, precisely determining causative genes and their interactions has remained elusive, due in part to difficulty in narrowing intervals to single genes and in detecting epistasis or linked quantitative trait loci.
For testing the causative pathway of gene environment interactions affecting inflammatory marker levels with consequent effect on the risk of MI, it would be advantageous to separately investigate fatal and non-fatal MI as an outcome.
