As the causative relationship between inflammation and cancer becomes increasingly established, evidence has emerged that classical tumor suppressors can influence inflammation and immunity through crosstalk, such as those between the p53 and NF-κB pathways (Baldwin, 2012).
Lipid peroxides are possible causative agent of inflammation, oxidative stress, metabolic malfunctioning and aging.
Animal models have been utilized to establish a causative relationship between inflammation and brain injury after SAH.
Moreover, the immunosuppressive behavior of CAPE has been evaluated in T-cells [ 29] because generally the causative agent for inflammation is T-cells [ 25].
Considering this reported efficacy of steroid therapy, a causative role of inflammation is suggested, which is supported by the high aqueous flare values detected in our study.
A complete approach would include the examination of numerous elements of complex interactions between the causative agent of inflammation, various immune cells, and immune mediators that are consequently present in the joint and the cells of joint tissues.
TGF β1 is considered to be the most important cytokine for lung fibrosis because it links possible causative processes including inflammation and fibroblast growth in the formation of this disease.
The causative association between inflammation and post-operative AF/AFL was further studied in the canine pericarditis model by suppression of the inflammatory response with steroids and HMG-CoA reductase inhibitors (statins).
Collectively, this epidemiological and genetic evidence might suggest a causative role of inflammation in the complicated process of prostate carcinogenesis, implicating the important contribution of immune cells in the prostate pathogenesis.
Intensive investigations with various animal models deficient in key molecules in the inflammatory pathway further provided solid evidence for the causative role of inflammation in the development of obesity-related insulin resistance.
