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While some think about senescence in terms of the latter interpretation, others have tried to formulate theories of genes, causative for senescence, that do switch expression with age, or whose expression does lead to a different outcome at different ages, while avoiding the logical problem that Kirkwood pointed out.
A possible explanation is that de novo feature selection is identifying residues that correlate with binding specificity, but without being causative; for example, residues that participate in functions of the homeodomains besides DNA binding, those that are shared due to common evolutionary descent, and/or those that co-vary due to structural constraints (Clarke, 1995).
That is, the patient is examined for causative agents that underlie the health issue.
Our study emphasizes the need for methodologies for constructing causative models that underlie connections among traits.
However, our results highlight a key problem with tests of macroecological biodiversity relationships, namely, the search for simple causative relationships that function across scales is likely to be less insightful than acknowledging the potential for a range of variables to be involved in driving emergent patterns.
Without haplotype analyses and functional studies it remains unknown whether rs3738919 is itself a disease-modifying variant or whether it is a signpost for a causative variant that has yet to be discovered.
Further in-depth studies with these models are needed to characterize the pore generation induced by h-IAPP, identify the cytotoxic mechanisms, screen for the causative factors that initiate toxic oligomer formation, and ultimately identify how these causative factors can be inhibited.
To investigate this possibility, we crossed cpdm mice with TNF-deficient mice, and were able to show that even partial genetic ablation of TNF prevented the formation of inflammatory lesions in cpdm mice, indicating that TNF-induced cell death is indeed causative for the inflammatory phenotype that characterizes these mice [ 19].
For instance, real causative mechanisms that lead to fatigue damage of pavement material might be frequency dependent.
This is also supported by the above discussion explained for understanding the causative factors that control the F− content in the groundwater.
The jury members apparently were not convinced by the conclusions of two generals who had investigated the Abu Ghraib scandal and found that Colonel Jordan's "tacit approval" of violent techniques by the military police during an episode in November 2003 was "the causative factor that set the stage for the abuses that followed for days afterward".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com