The challenge is to determine or distinguish between what arises from shared genetic determinants causative for multiple syndromes comprising a syndrome constellation, and what are secondary comorbidities.
Clinicians could also suggest the proper timing for large and expensive epidemiological trials, which should be performed exclusively when adequate metrics and reliable pathophysiologic causative mechanisms between determinants and outcomes have been established.
Key antigenic determinants of the causative agent, FMD virus (FMDV), reside within the surface-exposed proteins of the viral capsid.
But high initial death rates often fall as officials find that the causative microbe also causes mild, even symptomless cases.
Consequently, rather than being a direct determinant (i.e., causative risk factor) for invasive GAS infection, NSAID use could mark the onset of disease symptoms (fever, localized pain, and inflammation).
The clinical phenotypes of complex phenotypes are therefore likely to be due to individual effects of, and interaction between, multiple causative or contributory alleles, as well as non-genetic determinants.
As isolated cells were maintained in culture for several weeks prior to investigation, it seemed likely that the effects of pharmacological treatments (including metformin, a known activator of AMPK [ 8]) would be lost, allowing more accurate insight into molecular determinants of impaired endothelial function and potentially causative oxidative stress.
Although some progress has been made in the search for causative genes and variants associated with preterm birth, the major genetic determinants remain to be identified.
For many decades, the cornerstone of sepsis diagnosis and treatment has been identifying the causative circulating pathogen and quantitating single immune-related blood analytes -- medical determinants which are not necessarily specific to sepsis, but routinely evaluated to assess the patient's physiological response to the pathogen.
