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Organisms from these groups are the causative agents of human diseases such as malaria and African sleeping sickness.
Members of the Mycobacterium tuberculosis complex (MTC) are causative agents of human and animal tuberculosis.
EHV-1 is a member of the Alphaherpesvirinae and closely related to the causative agents of human chicken pox/shingles (varicella zoster virus, VZV) as well as cold sores and genital herpes, herpes simplex types 1 (HSV-1) and 2 (HSV-2) [1].
Several tick-borne rickettsiae are causative agents of human or animal diseases.
Fifty years ago, the idea that viruses might be causative agents of human cancers was controversial.
Hepatitis C virus (HCV) is one of the major causative agents of human hepatitis (Choo et al, 1989).
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In the apicomplexan parasites Plasmodium falciparum, the causative agent of human malaria, and Toxoplasma gondii, causing toxoplasmosis, LA metabolism has some peculiar features that might be exploitable for future drug development.
Unlike humans, almost all apicomplexan parasites, including Plasmodium falciparum, the causative agent of human malaria, and Toxoplasma gondii, causing toxoplasmosis, are now known to synthesize isoprenoids exclusively via the DOXP pathway in the apicoplast, an essential, metabolically active, reduced plastid of endosymbiotic descent found in almost all Apicomplexa [13].
Nonetheless, the closely related O. volvulus, causative agent of human river blindness, is an important cause of visual impairment, affecting >17.7 million globally and remains of major public health importance, especially in developing countries (20 ).
Mycobacterium tuberculosis, the causative agent of human tuberculosis, affects approximately two billion people world-wide, causing over three millions deaths each year.
A closely related virus named HTLV-2 is associated with relatively mild neurological disorders but has not been identified as a causative agent of human disease.
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