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The severity of this pathology requires a rigorous etiological investigation in order to determine the responsible infectious agent and propose a specific treatment of the causal infection, the only guarantee of a favorable evolution.
The causal infection was of bacterial origin in 58% of cases three cases of tuberculosis, one case of brucellosis, one case of rickettsial disease, one gram-negative bacilli septicemia and one staphylococcal septicemia.
Since the patients' details and isolates were not available for analysis, no direct causal infection route from the nasogastric tube can be made.
The correct diagnosis of the causal infection in sepsis may support the correct therapeutic choice, which is fundamental to avoid the continuous spread of specific pathogen/parasite triggers that will eventually lead to hyperinfection, and consequently to severe sepsis.
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The potential benefits of detecting and preventing causal infections, and the risks of interventions against unproven causal agents, are substantial.
Superimposed on human genetics and biology, the milieu shapes individual and population risk profiles for the causal infections agents and their chronic sequelae (7, 14, 21 ).
Older patients may present with secondary infections or with exacerbations of underlying chronic conditions, and these patients may not be tested for the causal viral infection.
Since this type of prevalence study does not allow one to draw any strong causal inferences between infection rates and excess mortality due to ICU-acquired infections, longitudinal cohort studies with more sophisticated analyses have to be conducted.
There is potential for individual or group stigmatization surrounding demonstrated or suggested causal links between infections, especially sexually transmitted infections, and increased risks for preterm labor or stillbirth.
Numerous potential causal factors including infection, immunisations, physical and emotional stressors, climate, diet, and occupational exposures have been studied using various observational study designs.
"Confirmation of a causal link between infection and microcephaly has transformed the profile of Zika from a mild disease to a devastating diagnosis for pregnant women and a significant threat to global health".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com