Sentence examples for causal diseases from inspiring English sources

Basic characteristics of program participants were based on the records: gender (categorical variable, 1 = male or 0 = female); age (continuous variable, number of years); and presence of reported causal diseases leading to disability.

Effective discovery of causal disease genes must overcome the statistical challenges of quantitative genetics studies and the practical limitations of human biology experiments.

For each locus, we applied a Bayesian refinement approach to define the subset of SNPs that, based on posterior probability, is 99% likely to contain the causal disease-associated SNP22 (https://github.com/chr1swallace/finemap-psa).

Labor intensive experiments are typically required to identify the causal disease variants from a list of disease associated variants in the genome.

Some of the remaining challenges for scientists searching for causal disease variants lie in: accessing data derived from cell types and tissues relevant to the disease under study; understanding how these functional units affect genes that may be distantly located7; and the ability to generalize such results to the entire organism.

Migrating partial seizures of infancy (MPSI) is a severe, pharmacoresistant, early-onset epilepsy syndrome associated with high morbidity and mortality in which the underlying causal disease mechanisms are poorly understood.

In this type of situation, the patient and his or her family must be informed that tracheotomy does not alter the prognosis of the causal disease.

Furthermore, we used disease associations and gene associations to predict causal disease genes.

Thus, Markov blanket methods can detect the causal disease SNPs with the fewest false positives.

Three patients (#2, 3 and 11) had a mono-allelic known causal disease mutation affecting the NPC1 gene, and one patient (#6) had a known causal disease mutation and an unclassified NPC1 allele variant (Table  1).

These results suggest that there could be a causal associated variant correlated with both rs10995190 and rs16917302, or alternatively more than one causal disease variant in this locus.