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For this diagram, three categories of screening (universal admission screening, targeted screening, and no screening) and three categories of isolation practices were distinguished.
The three categories of GO terms fell predominantly into one or two sub-categories.
Additional file 1: Table S1 contains full tables with all of the GO categories and clusters of GO categories enriched.
Because some genes had more than one functional GO category, the total number of GO categories matched is 1,872.
Categories of a GO term were defined as a set of the top parents that are accessible from the GO term through the GO graph structure.
When we combined these two groups into a single category of screening-detected cases, we found significant differences between the screening-detected and clinically diagnosed cases.
Interestingly, significant enrichment was also identified for another 14 GO categories, which is due to the nesting of GO categories.
We tested the list of validated targets for statistical enrichment of GO categories and pathways, using the initial 21,121 screened genes/factors as a reference (Table S3).
eGOn additionally allows for hypothesis testing of GO category representation.
For each GO category, the relative distribution of GO terms is represented in Figure 3.
These contigs were also annotated with Gene Ontology (GO) and were found to cover a broad range of GO categories.
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