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One such drug targets the nonsense category of mutation.
The study was not limited to a particular category of mutation, and the patients continued their standard therapies, such as antibiotics, during the trial.
Sensitivities were also assessed based on the category of mutation (Table 4).
Every category of mutation was represented among VWS families, whereas PPS mutations were limited to missense, nonsense, and splicing mutations.
On the other hand, one LOH type, a category of mutation imperceptible by aCGH, was detected in healthy controls.
The other general category of mutation is point mutation, nowadays referring to a single nucleotide change from one of the four kinds of nucleotide to another.
Similar(52)
One category of mutations produces a protein that is able to insert itself into the membrane of the cell but contains a "rusty gate" that closes off the passage of chloride.
This variant might be included in the above-described category of mutations that introduce proline residues.
As previously commented, the existence of a remarkable category of mutations, 'adaptive mutations', has stirred the community.
The third category of mutations is distributed across the entire polypeptide and may destabilize the overall protein fold by means of steric hindrance with a bulky residue (S22L, S38N, A297D, P357L and G381R), early termination of helical structure (L42P and L305P), and the disruption of salt-bridge contacts (R199C, K289N, R292C, E344A and R356P/Q/W) and β-turns (G336R and G378S).
These categories of mutation data are summarized in Table 1.
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Justyna Jupowicz-Kozak
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