A positive match was deemed present if the category of defect was the same for corresponding Octopus and Goldmann results.
Three broad categories of defects that can lead to a lupus-like phenotype have thus been defined in the mouse and are instructive for thinking about B-cell abnormalities in human SLE.
Using the collection of historic and newly identified loci involved in anther lobe cell fate specification and differentiation, we can now recognize four categories of defects and provide microscopic evidence and allelism test data to define distinct loci within each of these categories.
"A tenet of Six Sigma is that you take variability out of results," Mr. Deangelo explained, "and this enabled us to get rid of an entire category of potential defects, which is wrong, incomplete or late answers".
The category of skeletal defects potentially shows high representation because bone elements, such as vertebrae, femur, and ribs, are entered into the database as individual targets and further annotated by descriptions such as absent, incomplete ossification, or misshapen.
We could also include in this category of synthesis defects most splicing mutations and occasional missense mutations leading to highly unstable protein that is degraded rapidly, such as p.S205P [ 36].
Primary prevention of and prenatal screening for birth defects, optimal vaccination coverage and immunoprophylaxis for specific categories of birth defects will assist in reducing hospitalisation rates for ALRI.
The grouping of birth defects in our study was similar to the leading categories of birth defects in the general population as published by the March of Dimes and the Food and Drug Administration [ 15, 16].
Although all birth defects are documented, exclusion criteria have been developed by the Panel on the categories of birth defects which are not relevant.
