Three broad categories of defects that can lead to a lupus-like phenotype have thus been defined in the mouse and are instructive for thinking about B-cell abnormalities in human SLE.
Using the collection of historic and newly identified loci involved in anther lobe cell fate specification and differentiation, we can now recognize four categories of defects and provide microscopic evidence and allelism test data to define distinct loci within each of these categories.
"A tenet of Six Sigma is that you take variability out of results," Mr. Deangelo explained, "and this enabled us to get rid of an entire category of potential defects, which is wrong, incomplete or late answers".
The category of skeletal defects potentially shows high representation because bone elements, such as vertebrae, femur, and ribs, are entered into the database as individual targets and further annotated by descriptions such as absent, incomplete ossification, or misshapen.
We could also include in this category of synthesis defects most splicing mutations and occasional missense mutations leading to highly unstable protein that is degraded rapidly, such as p.S205P [ 36].
The small, medium and large categories of interfacial defect can be classified according to the beam type, defect location and defect size sequentially.
Two rabbits in the honey treated group showed improvement to moderate category of corneal epithelial defect at 72 hours whereas all the rabbits in the conventional treated group remained in the severe category.
Higher least square means were reached by ES samples with respect to controls in the total histological score, matrix, bone and edges categories, while they were equal in both ES and ED groups in the filling of defect category, and slightly lower in ES in respect to ED in the cartilage and degeneration categories (Additional file 1: Table S4).
