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In this research, pruning minhash values with more than one category association achieved the best results.
The gene-to-GO category association was based on the annotation provided by Ensembl Version 42 (http://www.ensembl.org).org
Using the 5 sets of QTL generated for each symptom category, association analyses using PLINK were performed with each set where the cases, in addition to being treated as a single group of 1867 cases vs. 2438 controls, were also divided into the 4 ASD subtypes that were determined by the ADI-R cluster analyses described above.
Primarily obtained from EBI, GO gene/protein to category association is available for 258 strains.
FunCat gene/protein to category association is available for 180 strains.
Bilateral activation of the category association condition reflects findings from investigations of young healthy participants [e.g., [ 20]], and from the current investigation's control group.
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We also used FuncAssociate to determine the overrepresented GO category associations of each of these four gene sets.
This is a necessary prerequisite to prevent cross category associations from exerting an influence on task performance [27], [41].
The identification tags are a set of descriptors that describe the context of the expression feature, such as the experiment type (RT-PCR or microarray) and the results including prognostic category associations.
= non-significant for category associations.
Additionally, we included GO gene to category associations by applying Blast2GO (Conesa et al., 2005).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com