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However, SIFT and other tools like it only attempt to distinguish between two classes of mutations, often categorized as deleterious and tolerated [3] or non-neutral and neutral [6].
When all non-synonymous changes are categorized as deleterious or neutral, using the program MAPP, we found both selfing genotypes of E. paniculata showed a slightly higher proportion of deleterious changes for the 4260 genes included in this analysis (transcripts with at least 5 homologous proteins and >60% identity in the protein alignments).
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All adverse events were categorized as mild.
Interestingly, the reported p53 mutations in NCI-H2122 cells (i.e., Q16L and C176F p53) are categorized as being only partially deleterious, suggesting the p53 pathway remains partially functional in these cells.
After the filtering by categorization, we were left with 14993 mutations categorized as either activating, neutral, or deleterious.
In these cases, the majority of changes are categorized as neutral, though in MRGPRX1 both human, Arg55Leu, and macaque, Arg55Cys, polymorphisms are predicted to be deleterious.
Some might be categorized as kitsch.
Both shootings are categorized as "friendly fire".
Extremely Photoshopped images were categorized as "oh, honey".
In some hospitals, mistakes are categorized as "E.T".
"Contingencies can be categorized as immediate, potential or unexpected".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com